Hep C Transmission Sexually: Understanding How, the Risks and Prevention

Written By Jaclyn P. Leyson-Azuela, RMT, MD, MPH
Published On
Hep C Transmission Sexually: Understanding How, the Risks and Prevention

Hep C transmission sexually is a common concern yet only few talk about. Hepatitis C (HCV) is a viral infection primarily affecting the liver. While it is commonly associated with parenteral transmission (e.g., blood-to-blood contact such as in cases of sharing needles for intravenous (IV) drug use), it is commonly a worry or a cause of concern whether it often happens with sexual activity.

This article aims to offer a comprehensive understanding of how Hepatitis C can be transmitted sexually. You will also understand the factors that could increase your risk and what you can do to prevent yourself from the infection. Even though the overall risk of sexual transmission for hepatitis C is considered very low, it is important to be aware of specific cases where transmission does occur. Understanding these subtle differences is important to make informed decisions regarding prevention and sexual health.

Key Insights

  • Hep C transmission sexually is rare but possible when it meets certain criteria or circumstances that involved blood-to-blood contact

  • Risk factors include co-infections with HIV, having multiple sexual partners, anal sex, and rough sex practices

  • Safer sexual practices like condom use and avoiding sex during bleeding or presence of sores are crucial for prevention

  • Hepatitis C is relatively curable, and the cure completely eliminates its transmission

  • Regular testing is therefore recommended for high-risk individuals or populations

How common is sexual transmission of Hepatitis C?

Sexual transmission of hepatitis C is generally considered uncommon or low. 

The Centers for Disease Control and Prevention (CDC) states that even when HCV is primarily transmitted through exposure to the blood of an infected individual, sexual transmission can still occur. This is true especially among certain group populations such as having multiple sex partners and practicing anal sex. It is stated that a small number of people can contract hepatitis C through blood exposure, which may occur during sexual activity.

What is the general risk of sexual transmission for Hepatitis C?

Chart explaining when sex becomes a risk for Hepatitis C with color-coded categories.

The general risk of sexual transmission for hepatitis C is low. This is in comparison to other transmission routes like sharing contaminated needles.

The reason for this low risk of transmission is because HCV is primarily a bloodborne virus. Sexual fluids typically do not contain enough viral load to transmit the virus. Transmission during sexual activity often requires direct blood-to-blood contact. For example, in long-term, monogamous relationships where one partner has hepatitis C, the risk of one partner transmitting the infection is quite low unless it meets other criteria or risk factors, like co-infection with HIV.

Why is Hepatitis C not considered a typical STI?

Hepatitis C is not considered your typical or usual Sexually Transmitted Infection (STI) because it is primarily not transmitted through sexual fluids. Unlike common STIs like chlamydia and gonorrhea, which you can get through sexual intercourse, hepatitis C may only be transmitted sexually if you meet certain criteria.

HCV transmission is when you get exposed to the blood of an infected person and it enters directly in your blood. While there may be occasions where sexual activity leads to blood exposure, it is not its primary MOT (mode of transmission). So it is distinct from the traditional STIs.

What factors increase the risk of Hepatitis C sexual transmission?

There are certain factors that can increase your risk of getting hepatitis C during sexual activity. These factors facilitate blood-to-blood contact such as specific sexual practices, presence of other sexually transmitted infections (STIs), and drug use during sex.

What specific sexual acts increase the risk of Hep C transmission?

There are specific sexual practices that increase the likelihood for blood-to-blood contact. This, in turn, significantly increases the risk of transmitting HCV. These include:

  • Anal sex–the practice carries the highest risk because the lining on the anus is more delicate and easily tears. This also increases bleeding during intercourse because microscopic tears may allow blood-to-blood contact.

  • Rough sex–any sexual activity that causes trauma, abrasions, or cuts to the skin or mucous membranes can create a venue for the HCV transmission.

  • Fisting–the practice, especially without proper lubrication or if it can cause micro-tears, may lead to trauma and bleeding. It makes it a high-risk activity for HCV transmission.

How does blood-to-blood contact occur during sex?

Parenteral contact during sex can also happen through different mechanisms, even without visible bleeding. These include:

  • Tears and abrasions–friction and vigorous activity cause small tears or abrasions in the genital or anal tissues. This creates open wounds, where the virus can seep through during sexual contact.

  • Open sores–the presence of open sores (particularly when there is co-infection of other STIs or other conditions) can open a direct route for HCV to enter your body.

  • Menstruation–sexual activity during menstruation increases the risk for blood exposure. It potentially facilitates transmission if the partner has HCV infection.

What role do other STIs play in increasing Hep C sexual transmission risk?

Bar chart showing relative risk ratings for different sexual practices.

If you have other STIs, it significantly increases your risk of getting HCV infection. It includes:

  • Herpes

  • Syphilis

  • Human Immunodeficiency Virus (HIV)

These conditions cause open sores, inflammation, or lesions in the anal or genital areas. These conditions may compromise the integrity of the mucous membranes and skin. It makes it easier for the virus to enter your blood during sexual contact. So people who are co-infected with other STIs are at increased risk for HCV transmission through sexual activity.

How does drug use during sex affect Hep C transmission?

Drug use during sex, specifically when it involves injection, is a major risk factor for HCV transmission. Sharing needles or other drug paraphernalia directly exposes you to HCV-infected blood. Even non-injecting drug use can indirectly increase the same risk.

For instance, snorting drugs can damage the nasal cavity, leading to bleeding, and sharing the drug-snorting equipment can facilitate blood exposure. Hence, HCV transmission. Also, drug use can impair judgment, which could lead to riskier sexual behaviors that further increases the risk.

What are the safe sex practices to prevent Hepatitis C?

Practicing safer sex can significantly reduce the risk of transmitting hepatitis C, particularly for people belonging to at-risk populations. Even when HCV is not primarily transmitted through sex, adopting certain precautionary measures can minimize your possible exposure to blood during sexual activity.

What are the recommended condom use guidelines for Hep C prevention?

Condoms are highly effective when it comes to preventing the transmission of STIs spreading through sexual fluids, even though it’s not 100%. HCV is bloodborne but condoms can still play an important role in minimizing your blood exposure during sexual activity. Condoms are recommended in situations where the blood exposure risk is higher, including:

  • With new or multiple sexual partners

  • Practicing anal sex, which carries a higher risk of bleeding or trauma

  • Having sex during menstruation

  • If either partner has open sores, cuts, open wounds, or bleeding in the anal or genital area

  • If either partner has co-infected with HIV or other STIs that cause lesions

Regular and correct use of condom can create a barrier against potential blood exposure. Thus, it reduces the risk of HCV transmission.

Are there specific hygiene practices to prevent Hep C transmission?

More than sexual activity, there are certain hygiene practices that are important to prevent HCV transmission. The virus can survive outside the body for a certain period. So it is important to avoid sharing personal care items that may have come in contact with blood or even minute amounts. These include:

  • Razors–a tiny nick can expose you to the blood present in it even microscopically

  • Toothbrushes–gums can bleed during brushing

  • Nail clippers–small cuts can happen around the nails, which could lead to blood exposure

These items should be for individual use only preventing unintentional blood exposure.

When should sexual activity be avoided to prevent Hep C transmission?

To further minimize the risk of hepatitis C infection and transmission, it is recommended to avoid sexual activity that increases the risk of exposure to body fluids like blood. It includes:

  • Having sex during menstruation–it can increase the risk for Hep C transmission because of the blood

  • Presence of open sores or cuts–having open wounds in the genital or anal area increases risk for transmission. Any sexual activity should be avoided until the open cuts, wounds, or sores have healed. This is especially important for people who have STIs that cause lesions, as these are breaches in the skin and mucosa, serving as an entry point for HCV.

By being familiar with these situations, you can significantly reduce your chances of getting HCV infection during sexual activity.

How does HIV co-infection impact Hepatitis C sexual transmission?

HIV Co-Infection Impact Chart showing differences between HCV Only and HCV+HIV Co-Infection with icons and text.

People who are co-infected with HIV and hepatitis C face a significantly higher risk of sexual transmission of HCV. The heightened risk is a crucial consideration for prevention and treatment strategies. The interplay between HIV and HCV can create a more ideal environment to transmit HCV through sexual encounters.

Why are individuals with HIV at higher risk for Hep C co-infection?

People with HIV are especially at risk for hep C co-infection because of a number of factors. Both viruses share a common transmission route, specifically through injection drug use (sharing of needles). But beyond this shared risk behavior, HIV infection alone can influence HCV transmission.

HIV is a condition where it weakens the immune system. It could lead to higher HCV viral loads and increased viral shedding. Hence, the transmission is more likely to occur. Furthermore, HIV-infected people may have higher prevalence of other STIs that cause genital or anal lesions. This further increases the risk of blood exposure during sexual activity.

What are the implications of Hep C and HIV co-infection?

Having both hep C and HIV as co-infection has severe implications. The presence of both viruses in your system can accelerate disease progression and complicate the treatment approaches further. People with both infections experience a more rapid progression to liver fibrosis, cirrhosis, and eventually ending up with liver failure as compared to those with HCV alone.

About 21% of people with HIV also have hepatitis C infection. The weakened immune system from HIV infection can make it more challenging to cure HCV infection or make it difficult to respond to treatment. So, early diagnosis and integrated management for both infections are important to mitigate long-term health consequences.

Should you get tested for Hepatitis C if you are sexually active?

Yes, you should get tested for hepatitis C if you are sexually active or belong to the high-risk populations. Regular testing is not only recommended; it is a must.

Regular testing allows for early detection. Thus, it gives ample time for timely management, preventing more severe liver damage and potentially stops further transmission of the virus. Given the asymptomatic nature of early HCV infection, regular testing is the only way you can confirm its presence. Hepatitis panel testing is often recommended to check your infection status.

Who should be tested for Hepatitis C, especially if sexually active?

The CDC recommends hepatitis C testing for at-risk populations, particularly sexually active individuals who possess certain risk factors. The recommendations emphasize risk-based approach to laboratory testing:

  • People with a history of injection drug use–even when it was a single instance or occurring many years ago

  • HIV-infected individuals–due to the increased risk of co-infection and sexual transmission

  • People with persistently abnormal liver enzyme tests particularly for at-home urine strips or liver testing

  • Recipient of blood transfusion or organ transplants before July of 1992

  • Healthcare and public safety workers after needle sticks, sharps, or mucosal exposure to HCV-positive blood

  • Children born to HCV-positive mothers

  • Anyone who wants to have HCV testing

For sexually active individuals, special attention should be paid to those who have multiple partners, a history of previous STI infection, or engaging in high-risk sexual practices.

What are the benefits of early Hep C diagnosis?

Early hepatitis C diagnosis offers a number of significant benefits, both for individuals and public health, including:

  • Access to cure–modern HCV treatments are very effective, with cure rates of more than 95% for many genotypes. Early diagnosis allows people access to these treatments before any significant liver damage occurs.

  • Prevention of disease progression–timely treatment can prevent the progression of HCV to chronic liver disease, liver cancer, cirrhosis, and avoid the need for liver transplantation.

  • Potential mitigation of transmission–diagnosing and treating HCV early potentially stops any individual from unintentional transmission of the virus, including sexual partners

  • Improvement of quality of life–a cure for hepatitis C can lead to improved overall health, decreased fatigue, and a better quality of life

Does curing Hepatitis C eliminate the risk of sexual transmission?

Stages of a cure process for a liver disease with icons and text on a white background.

Curing hepatitis C effectively eliminates the possibility of sexual transmission. It is a critical point for people who have achieved a sustained virologic response (virus is no longer detectable in the blood). A cure does not only improve your overall health but also removes the threat of transmitting the virus to others.

How does successful Hep C treatment affect transmission risk?

When an individual achieves a sustained virologic response (SVR–defined as an undetectable HCV RNA level in 12 weeks after completing therapy), it means that the individual has cleared the infection entirely and is considered cured. In this state, the person can no longer transmit the virus to others, which includes sexual contact since there is no viral load to spread. This significantly decreases the public health burden of HCV and allows people to live without the concern of transmission.

What are the long-term implications of a Hep C cure?

There are positive long-term implications for achieving hep C cure. It goes beyond eliminating the risk of viral transmission during sexual activity. A cure can lead to:

  • Improved liver health–the organ begins to heal and the risk of developing advanced liver disease like cirrhosis or cancer can be minimized

  • Reduction of mortality–cured individuals significantly lower the risk of liver-related and even all-cause mortality

  • Enhanced quality of life–resolution of HCV-related symptoms like fatigue, joint pain, or brain fog can lead to substantial improvement in their quality of life

Furthermore, patients can lead normal lives without the constant worry of liver disease progression, development of liver cancer, and transmitting the virus to other people.

Suggested Readings

Understanding the Acute Hepatitis Panel: What You Need to Know

Which Hepatitis is the Worst? Understanding Hepatitis

Quick Summary Box

  • Hepatitis C sexual transmission is rare but possible under specific circumstances involving blood-to-blood contact.

  • Risk factors include HIV co-infection, multiple partners, anal sex, and rough sex.

  • Safer sex practices, including condom use and avoiding sex during bleeding/sores, are crucial for prevention.

  • Hepatitis C is curable, and a cure eliminates the risk of sexual transmission.

  • Regular testing is recommended for at-risk individuals.

References
References

Can you get hepatitis C by having sex? The sexual transmission of hepatitis C among gay and bisexual men and other men who have sex with men. (2023, October 30). CATIE - Canada’s Source for HIV and Hepatitis c Information. https://www.catie.ca/prevention-in-focus/can-you-get-hepatitis-c-by-having-sex-the-sexual-transmission-of-hepatitis-c 

CDC. (2024). Viral Hepatitis Among Sexually Active Adults. Viral Hepatitis. https://www.cdc.gov/hepatitis/hcp/populations-settings/sexually-active.html 

Hep C factsheet: Sex and transmission. (n.d.). Retrieved July 5, 2025, from https://www.hep.org.au/wp-content/uploads/2024/04/Factsheet-Hep-C-sex_2.pdf 

HEPATITIS C & INJECTION DRUG USE. (2016). https://www.cdc.gov/hepatitis-c/media/pdfs/FactSheet-PWID.pdf 

Hepatitis C Virus/HIV Coinfection | NIH. (2023, January 31). Clinicalinfo.hiv.gov. https://clinicalinfo.hiv.gov/en/guidelines/perinatal/special-populations-hepatitis-c-virus-hiv-coinfection 

HIV and Hepatitis C | NIH. (2021, August 13). Hivinfo.nih.gov. https://hivinfo.nih.gov/understanding-hiv/fact-sheets/hiv-and-hepatitis-c 

NHS . (2019). Overview - Hepatitis C. NHS. https://www.nhs.uk/conditions/hepatitis-c/ 

Treating Hepatitis C. (2023, May 1). American Liver Foundation. https://liverfoundation.org/liver-diseases/viral-hepatitis/hepatitis-c/treating-hepatitis-c/ 

VA.gov | Veterans Affairs. (2020). Va.gov. https://www.hepatitis.va.gov/hcv/patient/sex/oral-and-anal-sex.asp 

Viral Hepatitis - STI Treatment Guidelines. (2021, July 19). Www.cdc.gov. https://www.cdc.gov/std/treatment-guidelines/hcv.htm 

World Health Organization. (2024, April 9). Hepatitis C. World Health Organization; World Health Organization: WHO. https://www.who.int/news-room/fact-sheets/detail/hepatitis-c 

 

Jaclyn P. Leyson-Azuela, RMT, MD, MPH
Written by Jaclyn P. Leyson-Azuela, RMT, MD, MPH

Jaclyn P. Leyson-Azuela, RMT, MD, MPH, is a licensed General Practitioner and Public Health Expert. She currently serves as a physician in private practice, combining clinical care with her passion for preventive health and community wellness.

Frequently Asked Questions

Q: Can Hepatitis C be transmitted through oral sex?
A: The risk of Hepatitis C transmission through oral sex is extremely low, as HCV is primarily transmitted through blood-to-blood contact. However, if there are open sores, cuts, or bleeding in the mouth or genital area, a theoretical risk exists.
Q: Is it safe to have sex with someone who has been cured of Hepatitis C?
A: Yes, once a person has been successfully treated and cured of Hepatitis C (achieved a sustained virologic response), they no longer have the virus and cannot transmit it to others, including through sexual contact.
Q: How often should sexually active individuals at higher risk get tested for Hepatitis C?
A: Sexually active individuals with ongoing risk factors (e.g., multiple partners, HIV positive, injecting drug use) should discuss regular Hepatitis C testing with their healthcare provider. Annual testing may be recommended for some high-risk groups.
Back to blog