Can Running Cause Elevated Liver Enzymes?

Are you a long-distance runner or an endurance athlete? If you are, then you might be surprised to learn that after your intense training sessions, you will have elevated liver enzymes. Many runners will notice temporary spikes in their liver enzyme levels if they get tested after training, and this may be a cause for concern for them. However, although this might look pathological, it is not necessarily a sign of liver damage. This spike is often a natural response to the physical stress of high-endurance activity.

Some of the liver’s main roles are energy processing, filtering of substances, and managing oxidative stress. During intense or prolonged exercise, the increased metabolic demand can lead to temporary elevations in liver enzymes such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transferase (GGT). These changes are typically temporary, but understanding their cause and looking at patterns over time can give you an insight to your liver’s health.

The Impact of Strenuous Exercise on Liver Function Tests

High-intensity running can influence liver function test results, and sometimes it mimics markers of liver stress. This happens because AST and ALT are not exclusive to the liver but also present in muscle tissue. When muscle fibers experience micro-tears and breakdown during strenuous exercise, these enzymes are released into the bloodstream, leading to temporarily elevated levels.

Liver enzyme elevations caused by exercise resolve as the body recovers. If you have persistently high liver enzyme levels or accompanying symptoms such as fatigue, nausea, or jaundice, you need medical evaluation to rule out underlying liver conditions.

Depending on your history, healthcare professionals may assess additional markers like bilirubin and creatine kinase (CK) to determine if the elevation is caused by liver dysfunction or muscle-related stress.

If you like working out, monitoring liver enzyme trends with at-home liver test kits can give you an overview of your health. Remember, though, that results should be interpreted in context with symptoms and professional guidance.

How Does Marathon Training Affect Liver Enzymes?

Marathon training is one of the most physically demanding endurance activities as it requires sustained energy output and prolonged muscle exertion. This results to post-race blood tests with temporary elevations in liver enzymes, particularly AST and ALT. Research has shown that marathon runners commonly experience higher-than-normal liver enzyme levels after a race, but these typically return to baseline within days with proper recovery.

Hydration, glycogen depletion, and muscle strain all contribute to enzyme fluctuations. These changes are generally harmless, however, if liver enzymes are persistently elevated in endurance athletes, it may be caused by overtraining, inadequate recovery, or potential underlying health concerns.

Symptoms of Elevated Liver Enzymes in Runners

Most runners with elevated liver enzymes do not experience noticeable symptoms. However, in some cases, the body may signal that something is amiss. Symptoms such as prolonged fatigue, nausea, dark urine, or mild abdominal discomfort could suggest that the liver is under additional stress. While these signs do not always indicate a serious issue, they warrant further attention.

For individuals experiencing persistent symptoms, consulting a healthcare provider is the best course of action. However, if you’re simply curious about how your liver responds to training, at-home liver test kits offer an accessible way to track enzyme levels and detect any unusual patterns.

Managing Liver Health During Intensive Running Programs

Running is an excellent way to improve cardiovascular health, endurance, and overall fitness, but it’s important to prioritize liver health alongside athletic performance. Implementing key recovery strategies can help maintain optimal liver function during intensive training periods:

·        Stay Hydrated - Dehydration can contribute to enzyme elevations, making fluid intake before, during, and after runs essential.

·        Support Recovery - Proper nutrition, including adequate protein intake, antioxidants, and essential nutrients, can help reduce oxidative stress and muscle breakdown.

·        Listen to Your Body - Overtraining without sufficient recovery can lead to prolonged enzyme elevation, increased inflammation, and potential injury.

Monitoring liver enzymes regularly can provide early indications of potential imbalances. At-home liver test kits like Ribbon Checkup allow you to track liver enzyme levels over time, ensuring you maintain a healthy balance between training and recovery.

Conclusion

So, can running cause elevated liver enzymes? Yes, but in most cases, it is a temporary physiological response rather than a sign of liver damage. The liver plays a crucial role in energy metabolism and recovery, and occasional enzyme spikes are part of the body’s natural adaptation to exercise.

For athletes and fitness enthusiasts, understanding these fluctuations and tracking patterns over time is key to maintaining overall health. Whether you’re a casual jogger or a seasoned marathon runner, monitoring liver enzyme levels with at-home test kits like Ribbon Checkup can provide valuable insights into how your body is responding to training. By balancing exercise with proper hydration, nutrition, and recovery strategies, you can continue to run strong while supporting long-term liver health.

References

Common Characteristics of Liver Disease. (2024, May 24). Johns Hopkins Medicine. https://www.hopkinsmedicine.org/health/conditions-and-diseases/common-characteristics-of-liver-disease

Creatine Kinase. (n.d.). https://medlineplus.gov/lab-tests/creatine-kinase/

Kalakonda, A., Jenkins, B. A., & John, S. (2022, September 12). Physiology, bilirubin. StatPearls - NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK470290/

Lippi, G., Schena, F., Montagnana, M., Salvagno, G. L., Banfi, G., & Guidi, G. C. (2011). Significant variation of traditional markers of liver injury after a half-marathon run. European Journal of Internal Medicine, 22(5), e36–e38. https://doi.org/10.1016/j.ejim.2011.02.007

Olson, G. (2023, November 14). What is delayed onset muscle soreness (DOMS) and what can you do about it? Healthline. https://www.healthline.com/health/doms#causes

Pavletic, A. J., Pao, M., & Wright, M. E. (2015). Exercise-induced elevation of liver enzymes in a healthy female research volunteer. Psychosomatics, 56(5), 604–606. https://doi.org/10.1016/j.psym.2015.03.002

Pettersson, J., Hindorf, U., Persson, P., Bengtsson, T., Malmqvist, U., Werkström, V., & Ekelund, M. (2007). Muscular exercise can cause highly pathological liver function tests in healthy men. British Journal of Clinical Pharmacology, 65(2), 253–259. https://doi.org/10.1111/j.1365-2125.2007.03001.x

Pinckard, K., Baskin, K. K., & Stanford, K. I. (2019). Effects of exercise to improve cardiovascular health. Frontiers in Cardiovascular Medicine, 6. https://doi.org/10.3389/fcvm.2019.00069

Reaver, A., & Gcingca, L. (2024, March 29). Muscle damage and elevated liver enzymes. InsideTracker. https://www.insidetracker.com/a/articles/muscle-damage-and-elevated-liver-enzymes