Fatty liver disease, especially non-alcoholic fatty liver disease (NAFLD), is affecting more people than ever. With its increasing prevalence, many are turning to supplements to support liver health in natural and holistic ways. Whether you're managing NAFLD, looking to improve liver function, or curious about preventative care, the right supplements can play a significant role in supporting your liver’s health.

This guide will explore the best natural supplements for fatty liver disease, focusing on NAFLD which is the most common cause of fatty liver globally, to provide helpful insights on their effectiveness and offer practical advice for those looking to heal or maintain liver health. 

What Causes Fatty Liver, and Why Supplements Can Help 

Fatty liver is caused by excess fat buildup in liver cells, often linked to lifestyle factors such as poor diet, obesity, insulin resistance, type 2 diabetes, and high triglycerides. Over time, this leads to inflammation and scarring, negatively impacting liver function. 

Understanding the early signs of liver damage is the first step for effective intervention.

Supplements enhance liver health by targeting specific root causes such as:

• Improving Insulin Sensitivity: Helping the liver manage sugar more efficiently. Read more about glucose monitoring at home.

• Reducing Fat Accumulation: Controlling fat storage and promoting fat breakdown in liver cells.

• Controlling Liver Inflammation: Antioxidant-rich supplements fight oxidative stress and reduce inflammation.

Quality supplements can be a powerful aid in reversing fatty liver changes when used alongside a healthy lifestyle. 

Can Supplements Help Reverse Fatty Liver? 

The question on many people's minds is "Can supplements reverse fatty liver disease?" While supplements alone may not cure fatty liver, they can certainly support healing when paired with diet changes, regular exercise, and weight management in addition to your provider's recommendations. 

Research suggests that supplements can reduce liver fat, improve liver enzyme levels, and lower overall inflammation in the body. For example:

• Omega-3 Fatty Acids have been shown to reduce liver fat and triglyceride levels. 

• Vitamin E has been found to improve liver inflammation for those with NAFLD. 

• Milk Thistle (Silymarin) is renowned for its ability to repair liver cells and fight oxidative damage. 

The key is consistency and making these supplements a part of a broader, healthy lifestyle. 

Vitamins and Supplements for Fatty Liver Support 

Certain vitamins and nutrients are essential for liver function and repair. Here are some of the top recommendations: 

1. Vitamin E 

What is it?
Vitamin E is a fat-soluble antioxidant that protects your cells, including liver cells, from oxidative stress. It's especially important for people with liver inflammation and cirrhosis.

What does the research show?
Research has shown that vitamin E can reduce liver inflammation and improve liver cell health in non-diabetic individuals with NAFLD. It's one of the few supplements with strong evidence in this group.

What are the risks?
At high doses, vitamin E may increase the risk of bleeding and has been linked to prostate cancer in some studies. It’s important to use it under medical supervision.

How much should you take?
The typical dose is 400–800 IU per day, but long-term use at high doses should be monitored by a healthcare provider.

2. Vitamin D 

What is it?
Vitamin D is essential for immune function, metabolic regulation, and overall cell health. Low levels of vitamin D are common in people with fatty liver and may worsen the condition.

What does the research show?
Several studies have found that low vitamin D levels are linked to more severe NAFLD. Supplementation may reduce liver fat and improve metabolic markers, though more research is ongoing.

What are the risks?
Vitamin D is generally safe at recommended doses. Excessive intake can lead to toxicity, causing symptoms like nausea, confusion, or kidney issues.

How much should you take?
Doses between 800 and 2,000 IU per day are commonly recommended. Getting your vitamin D levels tested can help guide appropriate supplementation.

3. B-Complex Vitamins

What is it?
B-complex vitamins are eight essential nutrients that support energy production, cell function, and liver detox—key for overall liver health.

What does the research show?
They help reduce inflammation and support liver enzyme function. Folate and B12 aid methylation, a crucial liver detox process. Supplementation may benefit those with poor diets or alcohol-related liver stress.

What are the risks?
Generally safe since they're water-soluble, but high doses of B6 can cause nerve issues, and excess niacin (B3) may lead to flushing or liver damage.

How much should you take?
Most supplements provide 100%+ of daily needs. Higher doses, especially of B12 or folate, should be taken with medical guidance.

4. Omega-3 Fatty Acids

What is it?
Omega-3 fatty acids are healthy fats found in fish oil and certain plant sources like algae. They're best known for supporting heart and brain health, but they also play a major role in liver health by reducing fat levels and inflammation.

What does the research show?
Studies show that omega-3s help reduce liver fat, lower triglycerides, and improve insulin sensitivity in people with NAFLD. This makes them particularly useful for those with metabolic issues.

What are the risks?
Omega-3s are safe for most people. Some may experience mild stomach upset, and high doses can increase bleeding risk, especially if you're on blood thinners.

How much should you take?
A common dose is 1,000 to 3,000 mg per day of combined EPA and DHA. Be sure to check labels and consult your doctor before going above this range.

5. N-acetylcysteine (NAC)

What is it? 

N-acetylcysteine (NAC) is an  an essential amino acid that helps produce cysteine. It's commonly used to treat acetaminophen (Tylenol) overdoses, preventing severe liver damage. NAC is also used for managing some lung conditions. 

What does the research show? 

NAC’s benefits as a daily supplement for liver health are less established. A small study suggested it may reduce liver inflammation in people with non-alcoholic fatty liver disease (NAFLD), but more research is needed to confirm long-term effects. 

What are the risks? 

As an oral supplement, NAC can cause side effects like nausea, vomiting, or diarrhea. Extremely high doses can be toxic, though this is typically a concern with intravenous (IV) treatments in medical settings. 

How much should you take? 

Participants in the NAFLD study took 600 mg twice daily, a dosage commonly suggested for NAC supplements. 

While NAC shows promise, consult your doctor before adding it to your routine.

6. Carnitine

 What is it?
Carnitine is an amino acid that helps convert fat into energy. It’s made in the body and found in red meat, fish, poultry, and dairy. Supplements may support liver function in people with NAFLD.

What does the research show?
Studies show carnitine can reduce liver enzymes, insulin resistance, and triglycerides in NAFLD patients. Doses of 300–2,000 mg per day over 3–6 months have shown benefits.

What are the risks?
Carnitine is generally safe but may cause nausea, stomach upset, or a fishy odor in some people. It may also interact with medications, so talk to your doctor before using it.

How much should you take?
Typical doses range from 300–2,000 mg daily. Work with a healthcare provider to find the right dose for you.

Top Herbal Remedies and Natural Supplements 

Nature has also provided us with powerful herbs to support liver health. Here are the most effective options backed by both tradition and science:

1. Milk Thistle (Silymarin) 

What is it?
Milk thistle is a medicinal plant that has been used for centuries to support liver health. Its main active ingredient, silymarin, is a potent antioxidant. 

What does the research show?
Several clinical studies have found that milk thistle can significantly improve liver enzymes such as ALT and AST in people with NAFLD. These enzymes are markers of liver inflammation. A large review even showed benefits in people with liver cirrhosis, a more advanced liver condition.

What are the risks?
Milk thistle is generally considered safe when taken at recommended doses. Rare side effects include gastrointestinal discomfort, headaches, or mild skin reactions like itching.

How much should you take?
Most supplements contain between 400–600 mg of milk thistle per day. Clinical studies have shown doses up to 2000mg being beneficial to NAFLD patients, but it’s always best to stay within labeled instructions or consult your healthcare provider.

2. Cinnamon

What is it?
Cinnamon is a spice with anti-inflammatory, antioxidant, and blood sugar-lowering effects that may help with NAFLD.

What does the research show?
Cinnamon (1,000–1,500 mg daily for 4–24 weeks) has been shown to lower liver enzymes, improve insulin resistance, reduce cholesterol, and decrease inflammation in people with NAFLD.

What are the risks?
Generally safe, but high doses of cassia cinnamon can harm the liver due to coumarin. It may also cause mild digestive issues and interact with diabetes or blood-thinning meds.

How much should you take?
1,000–1,500 mg daily. Ceylon cinnamon is safer for long-term use. Check with your doctor for the best type and dose.

3. Turmeric (Curcumin) 

What is it?
Curcumin is the main compound in turmeric, known for reducing inflammation and oxidative stress—key factors in nonalcoholic fatty liver disease (NAFLD).

What does the research show?
Studies show curcumin can lower liver enzymes, improve insulin sensitivity, and reduce liver fat. Doses of 80–3,000 mg daily for 8–12 weeks improved liver health.

What are the risks?
Generally safe, but high doses may cause mild digestive issues. It can interact with blood thinners and diabetes meds—talk to your doctor first.

How much should you take?
500–1,000 mg daily with black pepper extract (piperine) for better absorption. Look for “bioavailable” or “enhanced absorption” supplements.

4. Dandelion Root 

What is it?
Dandelion root has been used in traditional medicine as a liver tonic. It promotes bile production, which helps digest fats and detox the liver.

What does the research show?
While human data is limited, animal studies and traditional use suggest dandelion may support liver detox and protect liver cells from oxidative damage.

What are the risks?
Generally considered safe. Large amounts may cause diarrhea or allergic reactions in sensitive individuals.

How much should you take?
Typical supplement doses range from 500–1,500 mg per day. It’s also available as a tea or tincture.

5. Artichoke Leaf Extract 

What is it?
Artichoke extract is derived from the leaves of the artichoke plant. It’s rich in antioxidants like cynarin and luteolin, which help stimulate bile flow and support liver function.

What does the research show?
Clinical research suggests artichoke extract can lower ALT and AST liver enzymes, reduce fat accumulation, and protect against oxidative stress in the liver.

What are the risks?
Side effects are rare but may include gas or allergic reactions, especially in people allergic to ragweed or daisies.

How much should you take?
Common doses range from 300–1,000 mg daily, often divided into two doses with meals.

6. Licorice Root  (Deglycyrrhizinated Form – DGL)

What is it?
Licorice root is a traditional herb with anti-inflammatory and digestive-support properties. The deglycyrrhizinated form (DGL) is used to reduce potential side effects related to blood pressure.

What does the research show?
Some studies suggest licorice may reduce liver inflammation and improve fat metabolism. It may also protect liver cells from damage and aid in digestion.

What are the risks?
Standard licorice (with glycyrrhizin) can raise blood pressure or cause electrolyte imbalances. DGL is safer but should still be used moderately.

How much should you take?
Doses vary by product, but standardized DGL licorice is typically taken in 380–760 mg doses, up to twice daily.

7. Berberine

What is it?
Berberine is a natural compound found in several plants. It has anti-inflammatory and blood sugar-lowering properties, making it a potential aid for NAFLD.

What does the research show?
Berberine may improve liver enzymes, cholesterol, and blood sugar in people with NAFLD. Studies using 300–500 mg daily for 12–16 weeks have shown positive results.

What are the risks?
Berberine is generally safe but may cause digestive issues like constipation or cramping. It can interact with medications, especially for diabetes, so consult your doctor first.

How much should you take?
Typical doses are 300–500 mg daily for up to 16 weeks. Always check with your healthcare provider for personalized guidance.

These herbal remedies are best when sourced from high-quality, standardized extracts. 

Liver Detox & Cleanse: Myths and Reality

A common term you hear is “liver detox.” While the liver naturally detoxifies the body, some supplements can enhance its detoxification process effectively and safely. 

Safe Detoxifiers for Fatty Liver Include:

• Glutathione: A natural antioxidant central to liver detox. 

• N-Acetyl Cysteine (NAC): Converts into glutathione in the body, boosting its levels. 

• Alpha-Lipoic Acid (ALA): Protects against oxidative damage and assists metabolism. 

Also consider aids like urine bilirubin, and protein indicator strips, or understanding for better insight into body detox.

Avoid "quick-fix cleanses," as drastic measures can strain your body rather than help it. 

Many also wonder if fatty liver cause weight gain? The connection goes both ways and is addressed in depth.

Including these as part of your daily regimen can significantly benefit your liver health. 

Choosing the Right Supplement for You 

When selecting the best supplements for fatty liver, prioritize the following:

• Standardized Extracts for consistent potency. 

• Third-Party Testing such as USP or NSF certifications. 

• Clean Labels free from fillers and artificial additives. 

Always consult your healthcare provider, especially if you have existing medical conditions or take medications. 

Common Mistakes to Avoid 

To maximize your supplement’s benefits, avoid these errors:

• Overloading on too many supplements at once. 

• Ignoring proper diet and lifestyle changes. 

• Buying poor-quality, untested products. 

Remember, supplements are only part of the solution. A balanced diet and regular exercise remain essential. 

Final Thoughts on Fatty Liver Support 

Managing or reversing fatty liver takes more than just taking supplements. A balanced diet, regular exercise, and expert medical care are essential. Supplements like milk thistle, omega-3s, NAC, and curcumin can support liver health but what works best depends on your unique needs.

Always consult your healthcare provider to choose the safest, most effective approach for you. With consistency and the right guidance, real progress is possible.

Want to know more about fatty liver life expectancy or liver healing? Explore our in-depth resources.

Written by Abel Tamirat, MD
Dr. Abel Tamirat is a licensed General Practitioner and ECFMG-certified international medical graduate with over three years of experience supporting U.S.-based telehealth and primary care practices. As a freelance medical writer and Virtual Clinical Support Specialist, he blends frontline clinical expertise with a passion for health technology and evidence-based content. He is also a contributor to Continuing Medical Education (CME) programs.

 

Related Resources

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• Life Expectancy with Fatty Liver Disease: What You Need to Know
• Can Liver Function Tests Be Normal with Cirrhosis?

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